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Sixteen participants with medically documented nonorganic insomnia were randomly assigned to receive either a single dose and a 14-day administration of 600 mg of a standardized commercial preparation of valerian (LI 156) or placebo.

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For these reasons the very small apparent affect of medication use (Hedge's g = 0.1) should be interpreted with caution.

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ECG testing (Holter monitoring) compared to 106 non-fatigued control patients (p<0.03).

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